Publications

2025

Teresa Lobo, Guus H. Haasnoot, Aleksandra Nawrocka, Christine W. Bruggeman, Adria Razzauti, Erwin J.G. Peterman, Patrick Laurent. Sensory stimuli and cilium trafficking defects trigger the release of ciliary extracellular vesicles from multiple ciliary locations. https://doi.org/10.1101/2025.06.06.658075 

Longjun Pu, Lina Zhao, Jing Wang, Clementine Deleuze, Johan Henriksson, Patrick Laurent, Changchun Chen. Acute avoidance of hydrogen sulfide is modulated by external and internal states in C. elegans. https://doi.org/10.1101/2023.10.09.561535

Patrick Laurent. A jack of all trades: Hermaphrodite-specific serotonergic neuron in C. elegans. J of bioscience. http://doi.org/10.1007/s12038-025-00538-y

Rizwanul Haque*, Hagar Setty*, Ramiro Lorenzo*,  Gil Stelzer, Ron Rotkopf,  Yehuda Salzberg,  Gal Goldman, Sandeep Kumar, Shiraz Nir Halber, Andrew M. Leifer, Elad Schneidman, Patrick Laurent, Meital Oren-Suissa. A Blueprint of Sex-Specific Neuronal Regulation in the C. elegans Nervous System at Single-Cell Resolution. https://doi.org/10.1101/2024.12.27.630541

Aikaterini Stratigi*, Miguel Soler-García*, Mia Krout, Shikha Shukla, Mario De Bono, Janet E Richmond, Patrick Laurent (Feb 2025) Neuroendocrine control of synaptic transmission by PHAC-1 in C. elegans. Journal of Neuroscience. 10.1523/JNEUROSCI.1767-23.2024

2023

Razzauti A, Lobo T, Laurent P. Cilia-Derived Extracellular Vesicles in Caenorhabditis elegans: In Vivo Imaging and Quantification of Extracellular Vesicle Release and Capture. 10.1007/978-1-0716-3203-1_19

2022

Tchetan E, Ortiz S, Olounladé PA, Hughes K, Laurent P, Azando EVB, Hounzangbe-Adote SM, Gbaguidi FA, Quetin-Leclercq (Dec 2022) Fractionation Coupled to Molecular Networking: Towards Identification of Anthelmintic Molecules in Terminalia leiocarpa. J.Molecules. https://doi.org/10.3390/molecules28010076.

Njume FN, Razzauti A, Soler M, Perschin V, Fazeli G, Bourez A, Delporte C, Ghogomu SM, Poelvoorde P, Pichard S, Birck C, Poterszman A, Souopgui J, Van Antwerpen P, Stigloher C, Vanhamme L, Laurent P. (Oct 2022) A lipid transfer protein ensures nematode cuticular impermeability. iScience.  https://doi.org/10.1016/j.isci.2022.105357

2021

Razzauti, A. Laurent, P. (Sept 2021) Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons. eLife. https//doi: 10.7554/eLife.67670./2021.02.14.430969v1

2020

Lorenzo, R., Onizuka, M., Defrance, M., Laurent, P. (July 2020). Combining single-cell RNA-sequencing with a molecular atlas unveils new markers for Caenorhabditis elegans neuron classes. Nucleic Acids Research  https://doi.org/10.1093/nar/gkaa486

Martineau, C.N., Baskaner, B., Seinstra, R.I., Schafer, W.R., Brown, A.E.D, Nollen, E.AA, Laurent, P. (July 2020) Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state in C. elegans. PLOS Comp Biol  https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008002

2018

Laurent, P., Ch’ng, Q., Jospin, M., Chen, CC., Lorenzo, R., de Bono, M. (2018, july) Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron. PNAS. doi:10.1073/pnas.1714610115

2017

Chen, C.C., Itakura, E., Nelson, G.M, Sheng, M., Laurent, P., Fenk A.L., Butcher, R.A., Hegde, R.S., De Bono, M. (2017, february) IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature. doi:10.1038/nature20818

2016

Rabinowitch, I., Laurent, P., Zhao, B., Walker, D., Beets, I., Schoofs, L., Bai, J., Schafer, W.R., Treinin, M. (2016, January). Neuropeptide-Driven Cross-Modal Plasticity following Sensory Loss in Caenorhabditis elegans. PLoS Biol. doi: 10.1371/journal.pbio.1002348.

2015

Laurent, P*., Soltesz, Z*., Nelson, G.M., Chen, C., Arellano-Carbajal, F., Levy, E., De Bono, M. Decoding a neural circuit controlling global animal state in C. elegans. (2015, March) Elife, 11;4. doi: 10.7554/eLife.04241.* shared first author

2012

Busch, K. E*., Laurent, P*., Soltesz, Z., Murphy, R. J., Faivre, O., Hedwig, B., Thomas, M., Smith, H. L., & de Bono, M. (2012, April). Tonic signaling from O₂ sensors sets neural circuit activity and behavioral state. Nature neuroscience, 15(4), 581-591. doi:10.1038/nn.3061 *shared first authors Comment in: R. Benton, Nature Neuroscience 15(2012), 501-503.

2009

Persson A*, Gross E*, Laurent P, Busch KE, Bretes H, de Bono M Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans (2009).https://doi.org/10.1038/nature07820 Nature . *shared first authors

2005

Laurent, P*., Becker, J*., Valverde, O., Ledent, C., de Kerchove d’Exaerde, A., Schiffmann, S. N., Maldonado, R., Vassart, G., & Parmentier, M. (2005, December). The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10. Nature neuroscience, 8(12), 1735-1741. doi:10.1038/nn1585 *shared first authors