Our laboratory uses C. elegans as a genetic model to study the fundamental principles that govern nervous system function. How sensory neurons sense the environment through the sensory cilia, how neuromodulation control synaptic function, how circuits generate and maintain behaviour are several questions we are specifically interested in. C. elegans is well suited to address these questions: it has a simple and well-characterised nervous system; it is transparent. Several approaches are used including genetics, -omics, optogenetics, behaviour, and quantitative cell biology.